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KMID : 1059520090530060683
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Journal of the Korean Chemical Society
2009 Volume.53 No. 6 p.683 ~ p.692
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Synthesis, Magneto-Spectral, Electrochemical, Thermal Characterization and Antimicrobial Investigations of Some Nickel(II) Complexes of Hydrazones of Isoniazid
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Surendra Prasad
Ram K. Agarwal
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Abstract
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The synthesis of a novel series of nickel(II) complexes with new ligands derived from hydrazones of isoniazid have been reported in present work. The complexes have general compositions [Ni(L)2X2] or [Ni(L)3](ClO4)2 {L = N-isonicotinamido-furfuraldimine (INH-FFL), N-isonicotinamido-3’,4’,5’-trimethoxybenzaldimine (INH-TMB) or N-isonicotinamido-cinnamalidene (INH-CIN) and X = Cl-, NO3-, NCS- or CH3COO-}. The ligands hydrazones behave as neutral bidentates (N and O donor) through the carbonyl oxygen and azomethine nitrogen. The new complexes with octahedral geometry have been characterized by elemental analysis, molecular weight determinations, magnetic susceptibility/moment, thermogravimetric, electrochemical and spectroscopic studies viz. infrared and electronic spectra. On the basis of conductivity measurements in nitrobenzene (PhNO2) solution the [Ni(L)2X2] and [Ni(L)3](ClO4)2 complexes have been found to be non-electrolytes and 1:2 electrolytes, respectively. Thermal properties have also been investigated, which support the geometry of the complexes. Antibacterial and antifungal properties of nickel(II) complexes and few standard drugs have also been examined and it has been observed that the complexes have moderate antibacterial activities.
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KEYWORD
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Nickel(II), Complexes, Hydrazones, Biological activity
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